Of mice and men, periodic limb movements and iron: How the human genome informs the mouse genome

Abstract

The gene, BTBD9, was recently linked to restless legs syndrome, periodic limb movements and iron status in humans. In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis. This finding is important as iron status in brain has been implicated in restless legs syndrome. © 2008 The Authors.