Green-inspired synthetic drives for organophosphorus compounds under solvent-free conditions

Abstract

Organophosphorus chemistry is an exciting field of research. Phosphorus-functionalized organic molecules find practical and useful applications in such diverse areas as medicinal, pharmaceutical, agrochemical, and materials chemistries, both on laboratory and industrial scales. Green-chemistry principles are motivating the design and development of newer synthetic methodologies for such beneficial organophosphorus compounds and their analogues. Solvent-free conditions are associated with several practical benefits, including operational simplicity, cost-effectiveness, minimization of waste generation, and reduced pollution, all of which are very much crucial for industrial process development. This review summarizes solvent-free synthetic methodologies for functionalized organophosphorus compounds reported during the period 2016 through 2021.