Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers

Abstract

Background & aims: Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown. Methods: Incident cases (n = 1142) from a population-based case-control study were followed-up from diagnosis (1993-1995) until 2000. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for esophageal and gastric cancer in relation to prediagnostic factors. Results: Relative to distant stage, esophageal adenocarcinoma (EA) patients with localized disease had a decreased risk for death (HR,. 22; 95% CI,. 15-.31), followed by those with regional spread (HR,. 32; 95% CI,. 23-.45). Similar patterns were seen for the other tumor types. Except for other (non-cardia) gastric adenocarcinomas (OGA), higher household income ( <25 kg/m2. Women with esophageal squamous cell carcinoma (ES) and OGA experienced longer survival compared with men. Age, education, cigarette smoking, alcohol intake, gastroesophageal reflux disease, and nonsteroidal anti-inflammatory drug use did not consistently predict survival. Conclusions: Predictors of lengthened esophageal and gastric cancer survival included higher income (except in OGA), overweight (among EA and OGA patients), and female sex (among ES and OGA patients). © 2005 by the American Gastroenterological Association.