In vivo endoscopic multifunctional optical coherence tomography imaging of lungs periphery before and after bronchial thermoplasty

Abstract

We demonstrate the use of a motorized distal scanning endoscope to acquire in vivo data in lungs of severe-asthma patients before and after an asthma treatment procedure called bronchial thermoplasty. Conventional optical coherence tomography (OCT) intensity images and polarisation sensitive OCT images were extracted from the acquired data. PS-OCT endoscopy allowing the visualization and segmentation of airway smooth muscle layer - which plays a key role in bronchoconstriction during asthma attacks - showed its potential as means to evaluate the effectiveness of bronchial thermoplasty.