Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

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Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

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Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., … Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical Communications, 52(44), 7114–7117. https://doi.org/10.1039/c5cc08325g

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