New developments in diagnosis and treatment of eosinophilic esophagitis

Abstract

Eosinophilic esophagitis (EoE) is a chronic, allergendriven, immune mediated disease of the esophagus that progresses to esophageal fibrostenosis if not well treated. The aim of this review is to provide an update on recent clinical advances in the development of diagnostic and therapeutic approaches for EoE. At present, the diagnosis and disease monitoring for EoE rely on repetitive endoscopic evaluations and esophageal tissue acquisition for histopathologic analysis. Recent advancements in EoE diagnosis include transnasal endoscopy, endoscopic functional lumen imaging probe, and the emergence of non-invasive diagnostic tools including cytosponge, esophageal string test, and mucosal impedance probe. Biomarkers for EoE have not yet proven their clinical utility. The current treatment modalities for EoE are topical corticosteroid, proton-pump inhibitors, elimination diet, and dilation. Promising results from clinical trials are emerging for biologic agents that target the interleukin (IL)-13 and the IL-4/IL-13 receptor, specifically, RPC4046 and dupilumab. Especially, dupilumab is promising to become the orphan drug of EoE.