Signal cascades analysis in nanoprocesses with distributed database system

Abstract

The signal cascades are a number of successive biochemical reactions, occurring in the cells. In these reactions take part many proteins (often enzymes) and the entire process may be compared to the dominoes effect. The common term used for define a varied biochemical mechanisms regulating processes in the nanonetworks is signal transduction executed in the signal cascades. These processes can be realized in a closed area of space which contains proper quantities of substrates and a set of control molecules working in a pre-defined manner which was determined by their chemical construction, including changes of chemical activity reached usually by the conformational changes. Information about the signal cascades that happen in the various type of cells for given processes can be retrieved from the biochemical research accessible in the biochemical databases. In this work, the simulation process of the signal transduction in bio-nanoprocesses using the distributed database environment is presented and illustrated by the biological example. © Springer-Verlag Berlin Heidelberg 2005.