From Soil to Serum: Matrix-Specific Per- and Polyfluoroalkyl Substance Accumulation and Potentially Associated Environmental Exposure Determinants in Teenagers Residing near an Industrial Hotspot

Abstract

The extensive production and use of per- and polyfluoroalkyl substances (PFAS) over recent decades have resulted in their pervasive distribution in environmental compartments worldwide. PFAS concentrations in soil and biota near fluorochemical manufacturing facilities tend to be typically higher near hotspots, which suggests that the consumption of home-produced foods near such hotspots most likely results in higher human exposure. One prominent European hotspot is located near the 3M fluorochemical production facility in Zwijndrecht (Belgium), where the relative contributions of different exposure pathways remain insufficiently characterised. This study therefore aimed to assess the PFAS concentrations and compositional profiles in serum, dwellings and gardens of teenagers residing near this hotspot. Serum samples from teenagers, along with multiple environmental matrices (i.e., soil, compost, vegetables/fruits/nuts, chicken eggs, rainwater and indoor house dust) were analysed for 21 selected PFAS. Additionally, potential determinants of PFAS occurrence and distribution across matrices were investigated using detailed questionnaire data. We found perfluorooctane sulfonic acid (PFOS) to be the predominant compound in both soil and serum, while perfluorobutanoic acid (PFBA) was most dominant in rainwater, compost, house dust and pods. Perfluorobutane sulfonic acid (PFBS) was most abundant in fruits and chicken eggs, while perfluorododecanoic acid (PFDoDA) was predominant in rooting vegetables and nuts. N-methylperfluorooctane sulfonamidoacetic acid (MePFOSAA) was the dominant compound in fruiting, stem, and leafy vegetables. These results indicate differences in accumulation pathways among the different media and/or differences in affinities of different PFAS in the matrices. Additionally, several environmental and behavioural factors were identified as determinants for PFAS in soil, compost, tree fruits, fruiting vegetables, chicken eggs and house dust, providing insight into potential drivers of exposure variability. The most important factors were related to the soil characteristics, the composting of grass and weeds, the chicken feed (i.e., bread, commercial feed), the type and frequency of ventilation and the frequency of cleaning.