Serum Bilirubin Levels Can be Used as a Potential Biomarker in the Progression of Diabetic Nephropathy in Rats

Abstract

Background: Diabetes mellitus is a widespread syndrome and a major cause of morbidity and mortality all over the world. Diabetic nephropathy is a progressive and irreversible renal affection that may end by renal failure in sever conditions. Bilirubin is the end product of heme catabolism. It has been recognized as a strong antioxidant. Many studies relate bilirubin to diabetes.