Effect of ethanol extract of Syzygium cumini (L.) pulp on blood pressure and malondyaldehyde level of chronic restraint stress rats

Abstract

Chronic stress disturbs the equilibrium of oxidant-antioxidant redox in the human body which accelerates cellular aging lead to promotes earlier onset of age-related diseases. To against the chronic stress human body needs exogenous antioxidant. Syzygium cumini (L.) has high antioxidant activity due to it’s high anthocyanin content. Therefore, this plant is potential to develop as a natural antioxidant. The aim of the study was to investigate the effect of ethanol extract of S. cumini (L.) pulp on blood pressure and malondialdehyde (MDA) level of rats induced by restraint stress. Twenty male Wistar rats were used in this study which divided into 4 groups with 5 rats in each group i.e. normal control, negative control and 2 treatment groups which given ethanol extract of S. cumini (L.) pulp at doses of 100 and 200 mg/g body weight (BW), respectively. Restraint stress was carried out by placing the rats in restraint rat for 30 minutes daily for 7 days. Blood pressure was measured before and after the treatment while MDA level was measured after the treatment. One-Way ANOVA was used to analyze the data. The results showed that induction of the restraint stress significantly increased blood pressure of the rats (p<0.001). The administration of ethanol extract of S. cumini (L.) pulp significantly prevented the increase in blood pressure of chronic restraint stress rats (p<0.001). Furthermore, the MDA level of the treatment groups was significantly lower than that of negative control (p<0.05) indicating that ethanol extract of S. cumini (L.) pulp could prevent the increase in the MDA level. In conclusion, administration of ethanol extract of S. cumini (L.) pulp can prevent the increase in blood pressure and MDA level of chronic restraint stress rats. ABSTRAK