Unreported intrinsic disorder in proteins: Disorder emergency room

Abstract

This article continues an “Unreported Intrinsic Disorder in Proteins” series, the goal of which is to expose some interesting cases of missed (or overlooked, or ignored) disorder in proteins. The need for this series is justified by the observation that despite the fact that protein intrinsic disorder is widely accepted by the scientific community, there are still numerous instances when appreciation of this phenomenon is absent. This results in the avalanche of research papers which are talking about intrinsically disordered proteins (or hybrid proteins with ordered and disordered regions) not recognizing that they are talking about such proteins. Articles in the “Unreported Intrinsic Disorder in Proteins” series provide a fast fix for some of the recent noticeable disorder overlooks.