The significance of anti-Müllerian hormone concentration in seminal plasma for spermatogenesis

Abstract

Background: The function of anti-Müllerian hormone (AMH) in seminal plasma in adulthood is uncertain. We examined the significance of seminal AMH for spermatogenesis. Methods: We measured seminal concentrations of AMH in 39 oligozoospermic men (mean age ± SD, 32.7 ± 4.3 years) and 10 normal volunteers to examine the association of seminal AMH with spermatogenesis. The seminal concentrations of AMH in oligozoospermic men (149.3 ± 254.0 pmol/l) were significantly lower than in normal men (249.0 ± 167.7 pmol/l; P ± 0.0337). Seminal AMH concentration correlated significantly with sperm concentration (r = 0.339, P = 0.0350) and mean testicular volume (r = 0.440, P = 0.246). The serum concentration of LH (r = -0.365, P = 0.0241), but not FSH, testosterone or estradiol, correlated significantly with AMH concentration in seminal plasma. Conclusions: AMH in seminal plasma may be important for sperm production, and is a good marker for Sertoli cell development.