Synthesis of purinecarbonitriles by Pd(0)-catalysed coupling of halopurines with zinc cyanide

Abstract

Pd(0)-catalysed coupling of halopurines with zinc cyanide allows the smooth introduction of the cyano group into the purine 2-, 6- and 8-positions. Pronounced ligand effects were observed, and tetrakis(tri-2-furylphosphine)palladium(0) was found to be the catalyst of choice in reactions where tetrakis(triphenylphosphine)-palladium(0) failed. © Acta Chemica Scandinavica 1996.