Clinical outcomes in elective total hip arthroplasty in Parkinson’s disease: a systematic review of the literature

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain.1 The clinical manifestations can often be insidious and involve tremor, bradykinesia, rigidity contractures, dystonia and flexed posture.1,2 The burden of the disease has risen exponentially over the past decade and is estimated in 6.1 million individuals globally,3 with 1 million people suffering from the disease in the US alone.4