Asymmetric Mach-Zehnder interferometer based biosensors for Aflatoxin M1 detection

Abstract

In this work, we present a study of Aflatoxin M1 detection by photonic biosensors based on Si3N4 Asymmetric Mach-Zehnder Interferometer (aMZI) functionalized with antibodies fragments (Fab'). We measured a best volumetric sensitivity of 104 rad/RIU, leading to a Limit of Detection below 5 × 10-7 RIU. On sensors functionalized with Fab', we performed specific and non-specific sensing measurements at various toxin concentrations. Reproducibility of the measurements and re-usability of the sensor were also investigated.