Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?

Abstract

Interleukin-33 (IL-33), a member of the IL-1 family, is critically involved in the modulation of the activity of diverse range of immunocompetent cells. Essential roles have been implicated in cardioprotection, in both in-nate and adaptive immune responses in mucosal organs, and in the maintenance of adipose tissue cells. Ovethe past 10 years, several studies evaluated the usability of IL-33 as a biomarker in diseases of inflammatory annoninflammatory origin. Our group is currently evaluating the predictive role of serum IL-33 in acute kidney injur(AKI). The aim of the article is to discuss selected studies on IL-33 in different diseases and its potential role as biomarker molecule.