The role of non-structural protein nss in the pathogenesis of severe fever with thrombocytopenia syndrome

Abstract

Viral non-structural proteins, such as NSs of the newly emerging severe fever with throm-bocytopenia syndrome virus, are well established virulence factors, mediating viral pathogenesis and disease progression through various mechanisms. NSs has been described as a potent interferon antagonist and NF-κB agonist, two divergent signaling pathways in many immune responses upon a viral encounter. In this review, we highlight the many mechanisms used by NSs on the host that promote viral replication and hyper-inflammation. Understanding these host-pathogen interactions is crucial for antiviral therapy development.