Intermolecular gold-catalyzed diastereo- and enantioselective [2+2+3] cycloadditions of 1,6-enynes with nitrones

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Abstract

Going for gold: The title reaction has been developed and demonstrates a wide substrate scope with respect to the 1,6-enynes and nitrones (see scheme; DCE=1,2-dichloroethane, Tf=trifluoromethanesulfonyl). The results for the enantioselective versions are also presented. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Gawade, S. A., Bhunia, S., & Liu, R. S. (2012). Intermolecular gold-catalyzed diastereo- and enantioselective [2+2+3] cycloadditions of 1,6-enynes with nitrones. Angewandte Chemie - International Edition, 51(31), 7835–7838. https://doi.org/10.1002/anie.201203507

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