Two new alkylresorcinols from Homalomena wendlandii and their cytotoxic activity

Abstract

In the course of our search for antineoplasic agents from Panamanian Flora, two new alkylresorcinols: 1-(2,6-dihydroxyphenyl)octan-1-one (1) and (+)-1-(3- (1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-1-one (2), together with three known compounds, (1R, 2R)-1-(benzo[d][1,3]dioxol-5-yl)propane-1,2,3- triol (3), (+)-aptosimon (4) and (-)-sesamin (5), were identified from the leaves of Homalomena wendlandii Schott (Araceae). Their structures were established by 1D and 2D NMR and IR spectroscopic, and MS methods. Compound 2 exhibited IC50 values of 3.3, 5.8 and 4.0 μg/mL against MCF-7, SF-268 and H-460 cancer human cell lines, respectively.