Association of interleukin-10 promo ter single nucleotide polymorphisms -819 T/C and -592 A/C with aging

Abstract

Increased inflammatory activity is known to accompany aging. Single nucleotide polymorphisms of inflammatory mediator genes might therefore affect the aging process. Relation of eight SNPs (tumor necrosis factor-α [TNF-α] -1031 T/C, interleukin-10 [IL-10] -819 T/C, IL-1β-511 C/T, IL-6 -634 C/G, IL-18 -607 A/C, transforming growth factor-β [TGF-β] +869 C/T, matrix metalloproteinase-1 [MMP-1] -1607 1G/2G, and MMP-3 -1171 5A/6A) with age or gender was evaluated in 500 Japanese persons (mean age: 56.7 years old, range: 19-100) by the chi-square test. There was a significant association of IL-10 -819 T/C with age (p = .0026). The association remained significant after multivariate logistic regression analysis (odds ratio for an age interval for 1 year, 1.009; 95% CI, 1.002-1.016). Furthermore, the genotype distribution of IL-10 -819 T/C was completely consistent with that of -592 A/C. These data suggest that IL-10 -819 T/C and -592 A/C may be a promising candidate for an aging-related gene in a Japanese population. Copyright 2005 by The Gerontological Society of America.