From pathomechanisms to prediction, prevention and improved care of insulin-dependent diabetes mellitus in children

Abstract

Molecular biology, gene technology and immunology have extensively clarified the aetiology and pathogenesis of insulin-dependent diabetes mellitus (IDDM). It is now obvious that the genetic background of the individual, poorly characterized environmental factors and aggressive autoimmune phenomena in a complex interplay contribute to the progression to clinical IDDM. The IDDM risk associated with certain genetic markers, e.g. the risk alleles at various HLA loci, the most strongly predisposing gene region, and the mechanisms that mediate the genetic impact may differ in different populations. In Finland the accumulated genetic evidence is so convincing that two IDDM prevention studies have been initiated. One is a population-based prediction and prevention study, while the other is conducted in first-degree relatives of IDDM patients. Both studies rely on screening of newborn infants for IDDM susceptibility alleles at the HLA-DQB1 locus. Meanwhile, in the clinical care of children with IDDM, the importance of intensified and individualized insulin therapy in prevention of diabetic microangiopathy has become increasingly clear, and should be implemented in the care of most paediatric patients.