Modified synthetic peptides: from therapeutics to chemosensors

Abstract

Modified synthetic peptides have emerged as an exciting avenue for enhancing therapeutic efficacy and expanding the scope of applications in various disease contexts. Indeed, the inherent tunability of synthetic peptides has facilitated the creation of highly selective and responsive sensors capable of detecting specific analytes with precision. More recently, their unique structural diversity and chemical versatility has been elegantly adapted for use in supramolecular sensing platforms. This Perspective article highlights the synergistic interplay between modified synthetic peptides, therapeutic applications, and the sensing technologies that underscore the interdisciplinary nature of contemporary chemistry.