Steroids from the South China sea gorgonian Subergorgia suberosa

Abstract

From the South China sea gorgonian Subergorgia suberosa, two new steroids, (22E)-14α-hydroxy-cholesta-1,4,22-trien-3-one (1) and 3-(1′, 2′-ethandiol)-cholest-3β,5α,6α,11α-tetraol (2) were obtained, in addition to six known steroids. The structures of compounds 1 and 2 were determined by spectroscopic methods. Cytotoxicity of the six known steroids against human cancer cell lines A549, HONE1, and HeLa was evaluated by MTT methods, and their anti-larval activity was evaluated in settlement inhibition assays with laboratory-reared Balanus amphitrite and Bugular neritina larvae.