Very late-onset group b streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency

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Abstract

We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1β or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations. © 2009 by the Infectious Diseases Society of America. All rights reserved.

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Krause., J. C., Ghandil, P., Chrabieh., M., Casanova., J. L., Picard., C., Puel., A., & Creech, C. B. (2009). Very late-onset group b streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency. Clinical Infectious Diseases, 49(9), 1393–1396. https://doi.org/10.1086/630206

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