Convenient Synthesis of N -Protected Amino Acid Amides

  • Nozaki S
  • Muramatsu I
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Abstract

Boc- or Z-amino acids were conveniently amidated at room temperature by a one-pot procedure employing ammonium hydrogencarbonate and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in yields of 81–96%. The benzyl ester-type protector for the side chains of aspartic acid and glutamic acid was not affected by the procedure.

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Nozaki, S., & Muramatsu, I. (1988). Convenient Synthesis of N -Protected Amino Acid Amides. Bulletin of the Chemical Society of Japan, 61(7), 2647–2648. https://doi.org/10.1246/bcsj.61.2647

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