Modulation of FGF2 after topical application of Stichopus hermanii gel on traumatic ulcer in Wistar rats

Abstract

Background: stichopus hermanii (golden sea cucumber) is one of the many types of marine organisms containing glycosaminoglycans (GAGs), a polysaccharide that promote wound healing. The content of this GAGs, mainly dermatan sulfate, chondroitin sulfate and heparan sulfate has the ability to modulate FGF2. FGF2 many found in the oral mucosa to activate fibroblast proliferation. Purpose: The study was aimed to determine the modulation of FGF 2 after topical application of stichopus hemanii gel on traumatic ulcers in wistar rat. Methods: The sample was 36 male Wistar rats which were divided into 6 groups. C1 and C2 group was placebo gel, sC1 and sC2 group was stichopus hermanii gel, HA1 and HA2 was hyaluronic acid A gel. The gel was given shortly after the traumatic ulcer (TU) formed and 24 hour later. Then all rats were sacrificed lips mucosa were taken and ELIsA examination was done. results: All data were analyzed by ANOVA test followed by Tukey HsD. Test results show significant differences between sC1-sC2 with C1-C2 group, while the HA1-HA2 with C1-C2 group showed no significant difference. Conclusion: The study showed that modulation of FGF 2 increased after topical application of stichopus hermanii gel on traumatic ulcers in wistar rats.