Study of the relationship between FT3, FT4, and TSH with bone resorption indices in men with hypothyroidism

Abstract

Aim: This study aimed to find the effect of hypothyroidism in men on metabolism and bone mineral density. Method: The study included a patients group of 90 men suffering from hypothyroidism and 120 healthy subjects as a control group. The study comprised the estimation of the concentration of Blood free triiodo-thyronine (FT3), free thyroid hormone (FT4), thyroid stimulating hormone (TSH), bone resorption index type I collagen C-terminal peptide (CTX-1), the serum calcium (Ca2+), serum phosphorus (Pi3+), the bone mineral density of the lumbar spine and femoral neck. Results: In the hypothyroidism men group: (1) the bone mass was lower than the control group with significant differences, (2) the bone resorption index CTX-1 was significantly higher than that in the control group and calcium and phosphorus were not different from those in healthy control subjects, and (3) TSH was positively correlated with CTX-1. Male TSH and CTX-1 levels were positively correlated. Conclusions: There is bone loss in men with hypothyroidism, which may be related to increased bone resorption.