Involvement of STAT3 in immune evasion during lung tumorigenesis

Abstract

In a recent study, we have shown that ST AT3 expressed by tumor cells blunts antitumor immunity during carcinogeninduced lung tumorigenesis. ST AT3 inhibits the production of pro-inflammatory chemokines and MHC Class I chainrelated gene A. In contrast, ST AT3 promotes the expression of MHC Class I molecules. Consequently, ST AT3 promotes tumor cell resistance to NK cell-mediated cytotoxicity. © 2013 Landes Bioscience.