DOP006 Research gaps in diet and nutrition in inflammatory bowel disease. A topical review by ECCO

Abstract

Background: The role of diet in IBD has recently attracted substantial interest by the scientific community and dietary influences are likely to explain the rapid rise in disease epidemiology. Methods: The D-ECCO working group along with other ECCO experts reviewed the evidence looking at the role of diet and nutritional therapy in the onset, perpetuation and management of IBD. Results: Evidence pertinent to the role of diet in IBD is summarized collectively under three main thematic domains: i) the role of diet in IBD aetiology; ii) the role of diet as induction and maintenance therapy in IBD; and assessment of nutritional status and supportive nutritional support in IBD. Future research should: Address causation in the interaction between diet, microbiome and IBD Investigate the ability to modify the gut microbiota by dietary in-terventions, and its effect on disease activity Study the role of industrialized food, including, but not limited to nutrients, additives and processing in IBD Explore mechanisms of action of Exclusive Enteral Nutrition (EEN) Evaluating optimal food reintroduction following EEN Assess the optimal regimen of Partial Enteral Nutrition (PEN) for maintenance of CD and type of accompanying diet Evaluate the efficacy of elimination diets for induction and maintenance of remission in IBD Study evolution of malnutrition following diagnosis and whether this is predictive of disease outcomes Develop new biomarkers that can predict, diagnose, monitor intestinal failure or insufficiency in IBD Study mechanisms of food-related functional symptoms in IBD Study the efficacy and safety of dietary therapies for the management of functional symptoms in patients with inactive IBD Conclusions: This summary of research gaps is anticipated to be agenda setting for future research in the area of diet and nutrition in IBD.