Background: Urticarial vasculitis is a small vessel vasculitis characterized by long-lasting wheals. It was suggested omalizumab is well tolerated and effective in patients with hypocomplementaemic urticarial vasculitis. Objective: To evaluate the clinical response and safety of omalizumab for treating patients with normocomplementaemic urticarial vasculitis (NUV) in real-world setting. Methods: We collected data from a single-center. This study included patients with NUV who was received omalizumab therapy. During a 24-week study period, the clinical efficacy was evaluated by patient’s self-assessment instrument urticarial vasculitis activity score and Dermatology Life Quality Index. Results: Five patients with NUV were enrolled. Three patients received 6 doses of 150 or 300 mg omalizumab subcutaneously every 4 weeks. At 24-week follow-up, it was revealed improvement of clinical manifestations and reduction of urticarial vasculitis activity score and Dermatology Life Quality Index. At 24-week visit, mild wheals recurred in one patient who was only administrated with omalizumab for 4 times. One patient did not response to omalizumab therapy. No adverse events were recorded in the 5 patients. Conclusion: Omalizumab may be a potential choice in the treatment of patients with NUV in the real-world life.
CITATION STYLE
Liu, T., Bai, J., Ying, S., Li, S., Pan, Y., Fang, D., … Fang, H. (2021). Real-world experience on omalizumab treatment for patients with normocomplementemic urticarial vasculitis. Journal of Asthma and Allergy, 14, 433–437. https://doi.org/10.2147/JAA.S304099
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