SYNTHESIS OF SOME NOVEL N-SUBSTITUTED 2-(4-BROMO-PHENOXYMETHYL)-1H-BENZIMIDAZOLE DERIVATIVES AND THEIR ANTIMICROBIAL EVALUATION

Abstract

The synthesis of a series of novel substituted benzimidazole derivatives by the condensation of o-phenylenediamine (1) with 4-bromophenoxy acetic acid (2). The latter compounds were reacted with different alkyl, benzyl or acyl halides and alkyl or arylsulfonyl chlorides. The synthesized compounds were characterized by IR, 1 H-NMR, Mass spectroscopy and elemental analysis for their structures. All the synthesized compounds were tested for their potential anti-bacterial and anti-fungal activities. This exhibited some promising results towards testing organism in vitro.