Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation

Abstract

Background: The accumulation of activated leukocytes correlates with autoimmunity and is regulated by chemokines. Results: Tpl2-deficient macrophages display impaired chemokine receptor expression and migration under inflammatory conditions. Conclusion: Tpl2 promotes the induction and maintenance of macrophage chemokine receptor expression and cellular migration in vivo. Significance: Tpl2 inhibition may represent a treatment for autoimmune disorders by modulating chemokine receptor expression and preventing local accumulation of activated macrophages. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.