Lifestyle interventions for healthy brain aging: A protocol for systematic review and meta-analysis

Abstract

Background: The main objective of the present protocol is to assess the lifestyle interventions (eating habits, physical exercise, social and cultural participation) on the brain health as people age. Methods: We will look at the following database sources, “The Cochrane Library, PubMed, EMBASE, Web of Science, and Google Scholar,” for this protocol, which is standardized by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Protocols. Only Alzheimer's disease (AD) patients will be eligible, and no restriction will be placed on participant's gender, age, education, ethnicity, or other demographic characteristics. All the studies based on the impact of active intervention centered on lifestyle interventions, including eating habits, sleep patterns, and physical exercise on the cognitive and functional status in the elderly populations. The primary outcome is the effects of nutrition and lifestyle interventions on the patients with AD, and secondary outcomes include body mass index, body fat percentage, and muscle mass. Results: In this study, we hope to find lifestyle interventions, which could have a preventive effect on brain health as people age, in particular AD. Conclusion: The conclusion of our study would suggest that a healthy lifestyle interventions, defined on the basis of proper nutrition, sleep patterns, physical exercise, and social and cultural activities, can positively influence the cognitive consequences of healthy brain aging.