Microbiota: A key factor affecting and regulating the efficacy of immunotherapy

Abstract

Graphical Abstract 1. The changes of microbiota in different cancers under various immunothera-pies are summarised. 2. The mechanisms of bacterial translocation and by which microbiota influence efficacy of immunotherapy are discussed. 3. The strategies of regulating immunotherapy by gut microbiota modification are elaborated. 4. The interactions between immunotherapy, host and gut microbiota are illustrated. Clin. Transl. Med. 2023;13:e1508. wileyonlinelibrary.com/journal/ctm2 https://doi.