Anti-oxidant capacity and anti-tumor T cell function: A direct correlation

Abstract

Improving persistence and sustained function of effector CD8 + T cell response is key for achieving significant tumor control in adoptive T cell immunotherapy protocols. Our recent report shows that high anti-oxidant property is central to potent anti-tumor effector T cells, and directly correlates to CD62L hi central memory, low glycolytic and low mitochondrial membrane potential phenotype, all of which may be linked and contribute to better tumor control.