Formulation and Evaluation of Orodispersible Film of Hyoscine Butylbromide

Abstract

Orodispersible film is a newly advancing novel drug delivery dosage form, which is useful for the patients who are bedridden. It has the most advantages over the other dosage forms such as tablets, capsules etc. The objective of this study was to design and optimize ODFs for improved drug delivery. The orodispersible films were formulated using Hyoscine Butylbromide, HPMC E5, HPMC E15, β-Cyclodextrin, Sodium saccharin, PVP-400. The evaluation of ODFs encompasses various aspects, such as weight variation which was observed to be in the range of 0.030 ± 0.007mg to 0.064 ± 0.0181 mg, thickness which was in the range of 0.0116 ± 0.0028 to 0.02 ± 0.01 mm for the 4 formulation, Folding endurance had a range of 95 ± 1.0 to 110 ± 2.0 folds, the surface pH range was found out to be 6.03 ± 0.69 to 6.48 ± 0.50. The drug content displays a variation between 66.58 ± 0.87% to 76.56 ± 3.53%. Orodispersible films were disintegrated at a time ranging from 25 ±1 seconds to 32 ± 2 seconds. The in vitro dissolution of four formulations study revealed a variance ranging from 41.63 ± 0.776 to 88.7 ± 1.41% at 180 seconds. Upon analysing the four formulations that were prepared, it was determined that F2 exhibited a more rapid dissolution time, lower weight variation, faster disintegration time, and possessed an appropriate thickness.