Reflections on a 40-year career in drug design and discovery

Abstract

In this article, I reflect on a 40-year career in drug discovery at Bristol Myers Squibb that encompassed the cardiovascular, central nervous system and antiviral therapeutic areas. I share scientific observations made in the design and optimization of cAMP phosphodiesterase inhibitors, prostacyclin partial agonists, maxi-K ion channel openers, influenza and respiratory syncytial virus inhibitors, hepatitis C virus NS3/4A proteas, NS5A replication complex and NS5B polymerase inhibitors and inhibitors of HIV-1 attachment and maturation. [Figure not available: see fulltext.]