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A Greener Technique for Microwave-Assisted O-Silylation and Silyl Ether Deprotection of Uridine and Other Substrates

Chemistry (Switzerland) (2022) 4(4) 1714-1722
DOI: 10.3390/chemistry4040112
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Abstract

A single clean, good-yielding, environment-friendly microwave-assisted procedure for O-silylation of uridine with tert-butyldimethylsilyl chloride (TBDMSCl), 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) and potassium nitrate as catalyst under solvent-free conditions is reported. Subsequent silyl ether deprotection is accomplished with a reusable acidic resin via microwave irradiation. Both the silylation and desilylation protocols have been applied to a panel of alcohols of pharmaceutical interest.

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Pasqualini, C., Poggialini, F., Vagaggini, C., Brai, A., & Dreassi, E. (2022). A Greener Technique for Microwave-Assisted O-Silylation and Silyl Ether Deprotection of Uridine and Other Substrates. Chemistry (Switzerland), 4(4), 1714–1722. https://doi.org/10.3390/chemistry4040112

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