Serum CA-125 for early prediction of miscarriage

Abstract

Background: Miscarriage is defined as the loss of a pregnancy before 20 weeks of gestation or before the fetus reaches 500 g of weight. It is estimated that 30% of all pregnancies end in abortion. 20% occurs in subclinical form (before evidencing it with ultrasound) and 10% later of his clinical detection. Objective: To assess the level of Serum CA-125 inpregnant with threatened miscarriage. Patients and method:A case control study carried at Al-Zahra Teaching Hospital in the period from 1st of October 2018 to the 1st of April2019, in which167 pregnant respondents at 6-12 weeks of gestation (were calculated from last menstrual period), with regular cycles) were enrolled in the study, and divided into two groups: Case group (n=58) pregnant with threatened abortion and control group (n=109) normal pregnant women. Results: the mean serum level of CA-125 in case group (threatened miscarriage) was (51.2±22.9 IU/ml) and for control group was (22.3±6.7 IU/ml). It was found that the serum level of CA-125 were highly significantly increased in threatened miscarriage group than in normal healthy group (P<0.001) . In the cutoff value at (30.6 IU/dl) of serum CA-125 the sensitivity of the test to diagnose the miscarriage was (80%), sensitivity (87%), PPV (91.5%), NPV (88%) and the accuracy of the test was (83.5%). Conclusion: The level of Serum CA-125 was highly increasing in threatened miscarriage patients.