A comparison of the metabolism of HEOD (dieldrin) in the CF1 mouse with that in the CFE rat

Abstract

HEOD labelled with 14C was administered to CFE rats and CF1 mice and the excreted radioactivity was examined to characterize the various HEOD metabolites. In addition to the pentachloroketone and 9-hydroxy metabolites, the identities of two further metabolites of HEOD in the rat were established. These are a faecal metabolite, 6,7-trans-dihydroaldrindiol, and a urinary metabolite, the hexachlorohexahydromethanoindene-dicarboxylic acid, which may be formed by oxidation of the diol. Three of the rat metabolites, but not the pentachloroketone, were found in the excreta of the CF1 mouse. Where possible the quantity of radio-activity present as any given metabolite was determined. A sample of the new urinary metabolite of the rat was synthesized and shown to have an acute oral toxicity of >850 mg/kg in the CF1 mouse. Prior induction of enzyme activity appeared to affect the production of urinary metabolites of HEOD in the CFE rat but not in the CF1 mouse. © 1972 Pergamon Press Limited.