Quorum sensing inhibitory activity of giganteone a from Myristica Cinnamomea king against Escherichia coli biosensors

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Abstract

Malabaricones A-C (1-3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated.

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Sivasothy, Y., Krishnan, T., Chan, K. G., Wahab, S. M. A., Othman, M. A., Litaudon, M., & Awang, K. (2016). Quorum sensing inhibitory activity of giganteone a from Myristica Cinnamomea king against Escherichia coli biosensors. Molecules, 21(3). https://doi.org/10.3390/molecules21030391

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