Diabetes is a Disease Characterized by Impaired Proteostasis

Abstract

The discovery of insulin production by the pancreatic islet cell that required removal of the exocrine pancreas was a milestone discovery in endocrine medicine. It later became known that insulin synthesis is disrupted with the production of amyloid from amyloid fibrils, and that this process led to the burnout of the islet cell. It also was learned that the development of renal insufficient and failure in diabetes mellitus is associated with hyaline granules in the glomerulus as well as micro vascular disease. This process of protein misfolding disorder in either case is fundamentally a diabetic proteomic feature, which is also expressed in the brain under a number of circumstances, some of which are genetic.