Restoring colistin sensitivity in colistin-resistant gram-negative bacteria: combinatorial use of α-terpineol and colistin

Abstract

Colistin (COL) has emerged as a last-line therapeutic agent for gram-negative bacteria (GNB) infections. However, widespread antibiotic use has led to an alarming increase in the number of colistin-resistant (COL-R) strains. In this study, we demonstrate that combining COL with a plant-derived extract could effectively restore the susceptibility of COL-R GNB. A possible treatment plan for COL-R GNB is presented.