LKB1/AMPK/mTOR Signaling Pathway in Non-small-cell Lung Cancer

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Abstract

Links between cancer and metabolism have been suggested for a long time but compelling evidence for this hypothesis came from the recent molecular characterization of the LKB1/AMPK signaling pathway as a tumor suppressor axis. Besides the discovery of somatic mutations in the LKB1 gene in certain type of cancers, a critical emerging point was that the LKB1/AMPK axis remains generally functional and could be stimulated by pharmacological molecules such as metformin in cancer cells. In addition, AMPK plays a central role in the control of cell growth, proliferation and autophagy through the regulation of mTOR activity, which is consistently deregulated in cancer cells. Targeting of AMPK/mTOR is thus an attractive strategy in the development of therapeutic agents against non-small-cell lung cancer (NSCLC). In this review, the LKB1/AMPK/mTOR signaling pathway is described, highlighting its protective role, and opportunities for therapeutic intervention, and clinical trials in NSCLC.

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Han, D., Li, S. J., Zhu, Y. T., Liu, L., & Li, M. X. (2013). LKB1/AMPK/mTOR Signaling Pathway in Non-small-cell Lung Cancer. Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention. https://doi.org/10.7314/APJCP.2013.14.7.4033

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