BACKGROUND AND PURPOSE: Vessel imaging in acute ischemic stroke is essential to select patients with large-vessel occlusion for mechanical thrombectomy. Our aim was to compare the diagnostic accuracy of time-of-flight MR angiography and contrast-enhanced MR angiography for identification of vessel occlusion and collateral status in acute ischemic stroke. MATERIALS AND METHODS: One hundred twenty-three patients with stroke with large-vessel occlusion before thrombectomy were included in this retrospective study. Before thrombectomy, 3T MR imaging, including conventional 3D TOF-MRA of the intracranial arteries and contrast-enhanced MRA of intra- and extracranial arteries, was performed. Both techniques were assessed independently by 2 neuroradiologists for location of the occlusion, imaging quality, and collateral status. Findings were compared, with subsequent DSA as the reference standard. RESULTS: Both techniques had good interrater agreement of 0.74 (95% CI, 0.66 - 0.83) for TOF-MRA and 0.72 (95% CI, 0.63- 0.80) for contrast-enhanced MRA. Occlusion localization differed significantly on TOF-MRA compared with DSA (P .001), while no significant difference was observed between DSA and contrast-enhanced MRA (P .75). Assessment of collaterals showed very good agreement between contrast-enhanced MRA and DSA (94.9% with P .25), but only fair agreement between TOF-MRA and DSA (23.2% with P .001). CONCLUSIONS: Contrast-enhanced MRA offers better diagnostic accuracy than TOF-MRA in acute ischemic stroke. Contrast-enhanced MRA was superior in localizing vessel occlusion within a shorter acquisition time while providing a larger coverage, including extracranial vessels, and a more accurate assessment of collateral status. These results support inclusion of contrast-enhanced MRA in acute stroke MR imaging, perhaps making TOF-MRA superfluous.
CITATION STYLE
Boujan, T., Neuberger, U., Pfaff, J., Nagel, S., Herweh, C., Bendszus, M., & Möhlenbruch, M. A. (2018). Value of contrast-enhanced MRA versus time-of-flight MRA in acute ischemic stroke MRI. American Journal of Neuroradiology, 39(9), 1710–1716. https://doi.org/10.3174/ajnr.A5771
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