Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models

Abstract

The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine- resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.