Alveolus lung-on-a-chip platform: A proposal

8Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

Abstract

Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments because they can successfully simulate human physiology. In this review, we discuss the main respiratory diseases and their pathophysiology, how to model a lung microenvironment, and how to translate it to clinical applications. Furthermore, we propose a novel alveolus lung-on-a-chip platform, based on all currently available methodologies. This review provides solutions and new ideas to improve the alveolar lung-on-a-chip platform. Finally, we provided evidence that approaches such as 3D printing, organ-a-chip devices and organoids can be used in combination, and some challenges could be overcome.

Cite

CITATION STYLE

APA

Campillo, N., Oliveira, V. R., & da Palma, R. K. (2021, September 1). Alveolus lung-on-a-chip platform: A proposal. Chemosensors. Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/chemosensors9090248

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free