Cerebral perfusion reserve indexes determined by fluoromethane positron emission scanning

Abstract

An index of cerebral perfusion reserve (RES%), defined as the percent change of regional cerebral blood flow over baseline per mm Hg of end-tidal CO2 tension, was determined for each middle cerebral artery (MCA) territory in patients with unilateral carotid distribution transient ischemic attacks or minor ce re bro vascular accidents and was compared with that of age-matched, neurologically normal volunteers. Vasodilator responses to induced hypercapnia were tested during inhalation of 5% CO2 in 95% O2 while regional cerebral blood flow was measured by fluorome thane inhalation positron emission tomography. Mean RES% for 24 normal MCA territories was 5.2±0.8%. Mean RES% for 15 patient nonischemic MCA territories was 3.8 ± 1.3% and for 15 ischemic MCA territories was 2.8± 1.9% (both p<0.001). Individual RES% values and symmetry ratios between ischemic and nonischemic regions were also determined and compared with angiographic data. Areas of diminished, asymmetric, or paradoxical (two patients) CO2 reactivity appear to correspond to areas of compensatory vasodilation. We found this technique to be a safe and reproducible method for defining and recording localized areas of cerebral tissue at apparent risk for hemodynamically related damage. © 1988 American Heart Association, Inc.