A switchable dual organocatalytic system and the enantioselective total synthesis of the quadrane sesquiterpene suberosanone

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Abstract

The combination of aminocatalysis with N-heterocyclic carbene catalysis has been extended to a switchable dual catalytic system, which allowed a direct enantioselective entry to bridged bicyclo[3.n.1] ring systems and the total synthesis of the natural product (1R)-suberosanone.

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Ren, Y., Presset, M., Godemert, J., Vanthuyne, N., Naubron, J. V., Giorgi, M., … Coquerel, Y. (2016). A switchable dual organocatalytic system and the enantioselective total synthesis of the quadrane sesquiterpene suberosanone. Chemical Communications, 52(39), 6565–6568. https://doi.org/10.1039/c6cc01689h

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