Identification of a secondary promoter within the human B cell receptor component gene hCD79b

Abstract

Background: Transcriptional control of hCD79b is critical to B cell function and poorly understood. Results: A fully sufficient and novel secondary promoter was identified within intron 1 of hCD79b. Conclusion: hCD79b has a complex transcriptional structure comprising two competing promoters. Significance: The secondary promoter within hCD79b predicts novel pathways of B cell receptor expression in normal and pathologic settings. © 2013 by The American Society.